Ethnic differences in BDNF Val66Met polymorphism
نویسندگان
چکیده
منابع مشابه
Bdnf Val66met Polymorphism Modulates Sleep Intensity
335 BDNF Genotype and Sleep Intensity—Bachmann et al Moreover, in adult rats, the degree of exploratory behavior predicts the level of BDNF as well as of SWA during subsequent sleep.10 Finally, pharmacological experiments such as injections of exogenous BDNF, an anti-BDNF antibody, and an inhibitor of tyrosine kinase B receptor, the high-affinity BDNF receptor, consistently suggest that this re...
متن کاملThe BDNF Val66Met polymorphism is associated with structural neuroanatomical differences in young children.
The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism (SNP) has been associated with individual differences in brain structure and function, and cognition. Research on BDNF's influence on brain and cognition has largely been limited to adults, and little is known about the association of this gene, and specifically the Val66Met polymorphism, with developing brain ...
متن کاملBDNF Val66Met Polymorphism Influences Age Differences in Microstructure of the Corpus Callosum
Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and promotes axonal growth, but its secretion, regulated by a BDNF gene, declines with age. The low-activity (met) allele of common polymorphism BDNF val66met is associated with reduced production of BDNF. We examined whether age-related reduction in the integrity of cerebral white matter (WM) depends on the BDN...
متن کاملBDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects.
A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. We hypothesize that the BDNF Val66Met polymorphism may have a modulatory effect on the cardiac sympathovagal balance. A total of 211 healthy Chinese-Han adults (58 male, 153 female, aged 33.3 +/- 10.3 years) were recruited with thre...
متن کاملAllelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
Population stratification of functional gene polymorphisms is a potential confounding factor in genetic association studies. The Val66Met (rs6265) single-nucleotide polymorphism in the brain-derived neurotrophic factor gene (BDNF) exhibits one of the highest variabilities in terms of allelic distribution between populations. The present study reports the distribution of BDNF Val66Met alleles in...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2015
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.207.4.363